Papers

  1. Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA. (2018) Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras/Erk pathway. Science. Aug 31.
     
  2. Bugaj LJ, O’Donoghue GP, Lim WA. (2016) Interrogating Cellular Perception and Decision Making with Optogenetic Tools. J Cell Biol. Dec 21.
     
  3. Gordley RM, Bugaj LJ, Lim WA. (2016) Modular engineering of cellular signalling proteins and networks. Curr Opin Struct Biol. 13(39), 106-114.
     
  4. Bugaj LJ, Mesuda CK, Varedi M, Kane RS, Schaffer DV. (2015) Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nature Communications. 6, Article 6898.
     
  5. Yousef H, Morgenthaler A, Schlesinger C, Bugaj LJ, Conboy I, Schaffer DV. (2014). Age-Associated Increase in BMP Signaling inhibits Hippocampal Neurogenesis. Stem Cells. Published Online 12/1/2014.
     
  6. Yousef H, Conboy M, Morgnethaler A, Schlesinger C, Bugaj LJ, Paliwal P, Greer C, Conboy I, Schaffer DV. (2014). Systemic attenuation of TGF-β1pathway in old mice simultaneously rejuvenates neurogenesis and myogenesis by down-modulating MHC I β2 microglobulin. Oncotarget. 6(14), 11959-11978.
     
  7. Bugaj LJ, Choksi AT, Mesuda CK, Kane RS, Schaffer DV. (2013). Optogenetic protein clustering and signaling activation in mammalian cells. Nature Methods. 10(3), 249-25.
  8. Cao J, Arha M, Sudrik C, Bugaj LJ, Schaffer DV, Kane RS. (2013). Light-inducible Activation of Target mRNA Translation in Mammalian Cells. Chem Commun, 49(75), 8338-8340.
     
  9. Bugaj LJ and Schaffer DV. (2012). Bringing next generation therapeutics to the clinic through synthetic biology. Curr Opin Chem Biol. 16(3-4), 355-361.
     
  10. Khan M, Steppan J, Schuleri K, Ryoo S, Tuday E, Bugaj L, Santhanam L, Berkowitz T, Nyhan D, Shoukas AA, Berkowitz DE. (2012) Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve. Eur J Appl Physiol. 112(8), 2933-2941.
     
  11. White AR, Ryoo S, Bugaj L, Attarzadeh DO, Thiyagarajan S, Chen K, Attwater S, Abbot B, Li D, Champion HC, Shoukas AA, Nyhan D, Hare JM, Berkowitz DE, Tuday EC. (2010). Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway. Eur J Appl Physiol. 110(2), 395-404.
     
  12. Kim JH, Bugaj LJ, Bivalacqua T, Ryoo SS, Oh YJ, Soucy KG, Santhanam L, Camara A, Sikka G, Nyhan D, Shoukas AA, Champion HC, Berkowitz DE. (2009). Arginase Inhibition Restores NOS Coupling and Reverses Endothelial Dysfunction and Vascular Stiffness in Old Rats. J Appl Physiol. 107(4), 1249-57.
     
  13. Steppan J, Ryoo S, Schuleri KH, Gregg C, Hasan RK, White AR, Bugaj LJ, Khan M, Santhanam L, Nyhan D, Shoukas A, Hare J, Berkowitz DE. (2006). Arginase modulates myocardial contractility by a NOS-1 dependent mechanism. Proceed Nat Acad Sci USA. 103(12),4759-4764.